Good animal feeding plays a vital role in animal health & welfare and in the production of safe and quality products of animal origin. The increasing demand for proteins of animal origin has led to intensification of livestock production, mainly based on the use of industrial compound feed. This has led to an increasing use of selected feed grains and fodder seeds, pesticides and fertilizers, new and unconventional materials in the production of feed such as biofuel by-products and several others agro-industrial by-products. In the past years, several contamination episodes have raised attention on the importance of ensuring feed safety and on the need to prevent and control the presence of old and new hazards, such as dioxin, aflatoxins and other undesirable substances.